FAP+ fibroblasts differentially directs stromal-immune signaling in healthy and diseased lungs - LSC 2025 - Repairing the Lung: from single cells and tissue organisation to regenerative therapy

Poster Session 1

Chair(s): Corry-Anke Brandsma, Katherine Landwehr, Åsa Wheelock, Amy Wong, Charikleia Ntenti, Cengiz Goekeri, Martijn C. Nawijn

Session type: Poster Session

FAP+ fibroblasts differentially directs stromal-immune signaling in healthy and diseased lungs

Jelmer Vlasma

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Optimization of single-nucleus RNA sequencing for superior characterization of the airway wall cellular landscape in pulmonary disease

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Developing a novel method for visualizing cell-directed extracellular matrix remodelling for investigating lung regeneration mechanisms

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siRNA-mediated perturbations in human precision-cut lung slices coupled to time-resolved single-nuclei RNA-seq

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3D-Bioprinting of induced pluripotent stem cell-derived alveolar epithelial type 2 cells (iAT2) spheroids.

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Critical role for the TGF-?1/mTORC1 signalling axis in defining the transcriptional identity of CTHRC1+ pathologic fibroblasts in IPF

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TGF? induces changes indicative of neuroplasticity in a novel model of hPSC-derived sensory neurons.

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Reversing Bleomycin-Induced Lung Fibrosis through targeted MicroRNA inhibition: An ATII-driven therapeutical Approach for Alveolar Repair in IPF

Giulia Zandomenego

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Dissecting immunoproteasome function in lung regeneration using mouse lung organoid

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Benefits of bronchial epithelial repair by iPSCs in COPD

Marion Nadaud

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FAP+ fibroblasts differentially directs stromal-immune signaling in healthy and diseased lungs

Jelmer Vlasma

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Assessing therapeutic versus prophylactic efficacy of mesenchymal stem cells in LPS-induced lung injury model using BALB/c mice

Mogesh Sababathy

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Quantitative Assessment of Pulmonary Extracellular Matrix Remodelling as a Platform to Enable Regenerative Lung Interventions

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Tracing the origin of RSMCs in airway epithelial regeneration

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Lipid mediators control macrophage and fibroblast phenotype, and support regeneration in the alveolar niche

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Lipid hydrolysis fuels alveolar type 2 cell-mediated lung regeneration

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Investigating the Lipofibroblasts in post-ARDS regeneration

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The dual impact of TNF? on lung regeneration: divergent effects on epithelial cells and fibroblasts

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A novel model of short telomere related pulmonary fibrosis using alveolar epithelial type 2 cells generated from patient-derived induced pluripotent stem cells

Mari Ozaki

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Cell culture differentiation and proliferation conditions influence the in vitro regeneration of the human airway epithelium

Laure-emmanuelle Zaragosi

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Anti-fibrotic effects on extracellular matrix remodeling ex vivo: Insights from human lung slices and extended microphysiological system culture

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Investigating the mechanisms through which lung MSCs regulate endothelial functionality in COPD using distal lung organoid models

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mTOR dysregulation induces IL6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis.

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Emmanuelle Brochiero

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Lung Science Conference 2025

Repairing the Lung: from single cells and tissue organisation to regenerative therapy

20-23 March 2025 | Estoril, Portugal | #LSC2025

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