mTOR dysregulation induces IL6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis. - LSC 2025 - Repairing the Lung: from single cells and tissue organisation to regenerative therapy

Poster Session 1

Chair(s): Corry-Anke Brandsma, Katherine Landwehr, Åsa Wheelock, Amy Wong, Charikleia Ntenti, Cengiz Goekeri, Martijn C. Nawijn

Session type: Poster Session

mTOR dysregulation induces IL6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis.

Roya Babaei Jadidi

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Optimization of single-nucleus RNA sequencing for superior characterization of the airway wall cellular landscape in pulmonary disease

Sjors Maassen

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Developing a novel method for visualizing cell-directed extracellular matrix remodelling for investigating lung regeneration mechanisms

Isidora Kraguljac

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The airway epithelium in patients with asthma is in a continuous state of repair

Tessa Gillett

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Alveolar repair in COPD by reducing nitrosative/oxidative stress in pulmonary artery smooth muscle cells

Cheng-yu Wu

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siRNA-mediated perturbations in human precision-cut lung slices coupled to time-resolved single-nuclei RNA-seq

Ahmed Agami

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Alveolar type 2 cell senescence is a critical mechanism involved in the lack of repair during emphysema

Perla Abou Atmeh

Poster

3D-Bioprinting of induced pluripotent stem cell-derived alveolar epithelial type 2 cells (iAT2) spheroids.

Cormac Murphy

Poster

Critical role for the TGF-?1/mTORC1 signalling axis in defining the transcriptional identity of CTHRC1+ pathologic fibroblasts in IPF

Manuela Platé

Poster

TGF? induces changes indicative of neuroplasticity in a novel model of hPSC-derived sensory neurons.

Carli Koster

Poster

Reversing Bleomycin-Induced Lung Fibrosis through targeted MicroRNA inhibition: An ATII-driven therapeutical Approach for Alveolar Repair in IPF

Giulia Zandomenego

Poster

Dissecting immunoproteasome function in lung regeneration using mouse lung organoid

Kai Guo

Benefits of bronchial epithelial repair by iPSCs in COPD

Marion Nadaud

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FAP+ fibroblasts differentially directs stromal-immune signaling in healthy and diseased lungs

Jelmer Vlasma

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Assessing therapeutic versus prophylactic efficacy of mesenchymal stem cells in LPS-induced lung injury model using BALB/c mice

Mogesh Sababathy

Poster

Quantitative Assessment of Pulmonary Extracellular Matrix Remodelling as a Platform to Enable Regenerative Lung Interventions

Thomas Wilkinson

Poster

Tracing the origin of RSMCs in airway epithelial regeneration

Mahtab Shahriari Felordi

Poster

Lipid mediators control macrophage and fibroblast phenotype, and support regeneration in the alveolar niche

Melker Göransson

Poster

Lipid hydrolysis fuels alveolar type 2 cell-mediated lung regeneration

Thi Thanh Huyen Phan

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Investigating the Lipofibroblasts in post-ARDS regeneration

Georgios Kiliaris

Poster

Role of CFTR in airway epithelial differentiation and regeneration

Ines Pankonien

Poster

MMP14-generated endostatin drives vascular remodeling via Notch3 activation in idiopathic pulmonary arterial hypertension

Johannes Lorenz Berg

Poster

The dual impact of TNF? on lung regeneration: divergent effects on epithelial cells and fibroblasts

Rocío Fuentes-mateos

Poster

A novel model of short telomere related pulmonary fibrosis using alveolar epithelial type 2 cells generated from patient-derived induced pluripotent stem cells

Mari Ozaki

Poster

Cell culture differentiation and proliferation conditions influence the in vitro regeneration of the human airway epithelium

Laure-emmanuelle Zaragosi

Poster

Anti-fibrotic effects on extracellular matrix remodeling ex vivo: Insights from human lung slices and extended microphysiological system culture

Lena Willmer

Investigating the mechanisms through which lung MSCs regulate endothelial functionality in COPD using distal lung organoid models

Mark Bell

Poster

Cell-intrinsic mechanisms of lung regeneration and resilience over the lifespan

Gowtham Kumar Boosarpu Gopinath

Poster

mTOR dysregulation induces IL6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis.

Roya Babaei Jadidi

Poster

Therapeutic strategies to favor epithelial repair and regeneration in preclinical models of primary airway and alveolar cultures and live lung tissue

Emmanuelle Brochiero

Poster

Rejuvenation of airway basal stem cells by partial chemical reprogramming Mengyu Zou1, Qiaoyu Chen1, Ying Hua1, Wei Zuo1,2* 1Tongji Stem Cell Center, Tongji University, Shanghai, China 2Kiangnan Institute of Stem Cell, Hangzhou, China

Wei Zuo

Poster

N23Ps as a novel antifibrotic therapy: insights from 3D human fibrosis model and single-cell profiling

Diana L Porras Gonzalez

Poster

Lung Science Conference 2025

Repairing the Lung: from single cells and tissue organisation to regenerative therapy

20-23 March 2025 | Estoril, Portugal | #LSC2025

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