Exploring the antifibrotic potential of the heparan sulfate mimetic OTR4120 - LSC 2025 - Repairing the Lung: from single cells and tissue organisation to regenerative therapy

Poster Session 2

Chair(s): Niki L. Reynaert, Peter Pennitz, Mogesh Sababathy, Perla Abou atmeh, Carsten Schmidt-Weber, Ken Bracke, Ahmed Agami

Session type: Poster Session

Exploring the antifibrotic potential of the heparan sulfate mimetic OTR4120

Manuela Marega

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Aging affects reprogramming of murine pulmonary capillary endothelial cells after lung injury

Marine Isola

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Targeting the Fibrotic Phase of Diffuse Alveolar Damage: Early Pathways for Post-COVID-19 pulmonary fibrosis

Sabrina Setembre Batah

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Development of novel therapeutics against idiopathic pulmonary fibrosis with potent antifibrotic effects and unique mode of action.

Kevin Merchant

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Molecular and Spatial Transcriptomics Analysis in Silica-Induced Pulmonary Fibrosis

Nebal Abu Hussein

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DNA methylation as a driver of lung fibroblast senescence in COPD

Yin Lyu

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In-vitro analysis of cellular bioenergetics reveal a reduced mitochondrial spare respiratory capacity in bronchial epithelial cells of COPD patients

Arda Tarcan

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Defining the Prototype of Immune Cell Driven Fibrotic Tissue Organization in Restrictive Allograft Syndrome and Pleuroparenchymal Fibroelastosis

Lena Maureen Leiber

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Lineage tracing reveals the fate of lung endothelial cells in the progression of pulmonary fibrosis

Elisabeth Fließer

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Baddini-Capelozzis Necrosis

Alexandre Todorovic Fabro

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Iron-loaded alveolar macrophages alter alveolar type 2 epithelial cell function in COPD

Sophia Wugk

Poster

Counteracting pulmonary vascular endothelial cell senescence to combat age-related lung dysfunction and pulmonary hypertension

Juliette Jacquet

Poster

In Vitro Microfluidic Breathomics: epithelial volatiles and whole patient breath in COPD

Brady Rae

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Bleomycin induces long-lasting fibrosis in premature aging ERCC1?/- mice.

Zahra Khalajzeyqami

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Female sex hormones change the antiviral response of the bronchial epithelium in women with severe asthma

Cornelia Blume

Extracellular vesicles with HSP90 promote pulmonary fibrosis.

Léo Biziorek

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Oxidative and nitrosative stress in pulmonary vessels contribute to vascular remodelling and emphysema development in COPD

Stefan Hadzic

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Increased P2 purinergic signalling in circulating monocytes of patients with progressive pulmonary fibrosis

Luke Forde

Poster

Identification of genetic modifying factors of lung disease in PI*ZZ Alpha-1 Antitrypsin Deficiency and their role in alveolar cells

Nerea Matamala

Poster

Pulmonary glycosaminoglycans and fucosylation regulate lung barrier function and defense against S.pneumoniae

Cengiz Goekeri

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Role of Ferroptosis in the interplay between metabolically distinct macrophages and lungs cells in the context of Idiopathic Pulmonary Fibrosis

Julia Sauer

Poster

Elucidating the Mechanobiology of COPD Fibroblasts: The Role of Yes-Associated Protein (YAP)

Bryan Falcones Olarte

Poster

Bronchoconstriction damages airway epithelia by crowding-induced excess cell extrusion

Dustin Bagley

Poster

The role of ferroptosis and its inhibition in COPD

Silke Geirnaert

Poster

Exploring the antifibrotic potential of the heparan sulfate mimetic OTR4120

Manuela Marega

Poster

Divergent roles of senescent endothelial cells in the development of pulmonary arterial hypertension

Elmira Safaie Qamsari

Poster

Desmoplakin loss induces Wnt/?-catenin-dependent fibrotic gene expression and promotes pulmonary fibrosis development

Pooja Singh

Poster

The bacterial lysate OM-85 mitigates HDM-induced allergic inflammation through airway epithelial cell- macrophage crosstalk

Athanasios Kouklas

Poster

Bronchial transcriptomics identifies distinct endotypes of severe COPD

Maidinuer Saimi

Poster

Development of a chronic in vitro fibrotic model to investigate the role of DDR1 and DDR2 in lung fibrogenesis.

Annabel Kunzemann Martinez

Poster

Sex hormones modulate the onset of pulmonary fibrosis in type 2 alveolar epithelial cells

Anja Schweikert

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Imaging mass cytometric analysis of human fetal lung development reveals close interactions between epithelial and immune cells.

Padmini P. S. J. Khedoe

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Female-specific biological aging is associated with asthma.

Karosham Reddy

Poster

TCF21 Deficiency Induces Fibroblast Apoptosis and Promotes Fibrotic Changes in the Human Lung Mesenchyme

Stephanie T. Pohl

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Peptidyl-arginine deiminases as bactericidal and anti-biofilm agents against Pseudomonas aeruginosa

Rory Baird

Poster

Identification of epithelial properties driving airway remodeling in severe asthma

Laure-emmanuelle Zaragosi

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MEOX2-mediated epigenetic remodelling of lung epithelial cells in COPD and lung malignancy

Priscila Pineda Villegas

Poster

Lung Science Conference 2025

Repairing the Lung: from single cells and tissue organisation to regenerative therapy

20-23 March 2025 | Estoril, Portugal | #LSC2025

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